Direct association between C-reactive protein serum levels and endothelial dysfunction in patients with claudication

Eur J Vasc Endovasc Surg . 2008 Apr;35(4):480-6. doi: 10.1016/j.ejvs.2007.10.016. Epub 2008 Feb 20.

Fecha de la publicación: 01/04/2008

Autor: J De Haro 1, F Acin, A Lopez-Quintana, F J Medina, E Martinez-Aguilar, A Florez, J R March



1Angiology and Vascular Surgery Service, Hospital Universitario Getafe, Madrid, Spain.


Objectives: To evaluate the relationship between C-Reactive Protein (hsCRP), a serum marker of inflammation, and endothelial dysfunction in patients with intermittent claudication.

Design, patients and methods: Cross-sectional study with stratified sampling on dependent variables of age, genre, hypertension, hyperlipidemia, diabetes, smoking status and ankle-brachial index (ABI) to select 156 patients from a target population of 4,100 patients with claudication. We assessed the flow-mediated arterial dilation (FMAD) as a reporter of endothelial function and plasma levels of hsCRP and fibrinogen.

Results: Patients with a FMAD<3% (range for the lowest 5% of healthy subjects) had increased levels of plasma hsCRP (6.3 vs 2.3mg/L; p<0.05) and fibrinogen (351vs 302mg/L; p<0.05) in comparison to those with FMAD>3%. There was a negative correlation between hsCRP and FMAD(r=-0.465; p<0.05).

Conclusion: Impaired endothelial dysfunction is association with increased plasma concentrations of inflammatory markers, and both may have a role in the aetiopathogenesis of peripheral arterial disease.