Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall

iomed Res Int . 2020 Dec 14;2020:6782659. doi: 10.1155/2020/6782659. eCollection 2020.

Fecha de la publicación: 14/12/2020

Autor: Miguel A Ortega (1), Oscar Fraile-Martínez (1), Ángel Asúnsolo (2), Clara Martínez-Vivero (1), Leonel Pekarek (1), Santiago Coca (1), Luis G Guijarro (3), Melchor Álvarez-Mon (1, 4), Julia Buján (1), Natalio García-Honduvilla (1), Felipe Sainz (2, 5)



1Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Ramón y Cajal Institute of Sanitary Research (IRYCIS), University Center for the Defense of Madrid (CUD-ACD), Alcalá de Henares, 28047 Madrid, Spain.

2Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcala, Ramón y Cajal Institute of Sanitary Research (IRYCIS), Alcala de Henares, Madrid, Spain.

3Department of System Biology, Unit of Biochemistry and Molecular Biology (CIBEREHD), University of Alcala, Alcalá de Henares, Spain.

4Immune System Diseases-Rheumatology, Oncology Service and Internal Medicine, University Hospital Príncipe de Asturias (CIBEREHD), Alcalá de Henares, Madrid, Spain.

5Angiology and Vascular Surgery Service, Central University Hospital of Defense-UAH, Madrid, Spain.


Chronic venous disease (CVeD) has a remarkable prevalence, with an estimated annual incidence of 2%. It has been demonstrated how the loss of homeostatic mechanisms in the vein wall can take part in the physiopathology of CVeD. In this regard, it has been described how different axis, such as IGF-1/PAPP-A/STC-2 axis, may play an essential role in tissue homeostasis. The aim of this research is to study both genetic and protein expressions of the IGF-1/PAPP-A/STC-2 axis in CVeD patients. It is a cross-sectional study in which genetic (RT-qPCR) and protein (immunohistochemistry) expression analysis techniques were accomplished in saphenous veins from CVeD patients (n = 35) in comparison to individuals without vascular pathology (HV). Results show a significant increase in both genetic and protein expressions of PAPP-A and IGF-1, and a decrement STC-2 expression at the same time in CVeD patients. Our study is a pioneer for demonstrating that the expression of the different components of the IGF-1/PAPP-A/STC-2 axis is altered in CVeD patients. This fact can be a part of the loss of homeostatic mechanisms of the venous tissue. Further research should be destined to deepen into alterations of this axis, as well as to evaluate the usage of these components as therapeutic targets for CVeD.